Life Extension Protocols

Aging isn’t a mystery anymore. Over the past two decades, research has identified specific biological mechanisms that drive cellular aging — mTOR overactivation, mitochondrial decline, cellular senescence, NAD+ depletion, epigenetic drift, and chronic low-grade inflammation. More importantly, we now have pharmaceutical tools that target each of these mechanisms directly. The science is here. What’s been missing is a medical practice willing to prescribe, monitor, and adjust these protocols with the same rigor applied to any other chronic disease management.

At Longitude Life, life extension isn’t a buzzword — it’s a clinical program. Every longevity protocol is built on your DECODE diagnostic foundation, prescribed by your physician, and monitored with quarterly labs. We don’t hand you a bottle and wish you luck. We track biomarkers, measure biological age, and adjust your protocol as the science and your data evolve.

Key Longevity Compounds

Rapamycin (Sirolimus) — An mTOR inhibitor originally developed as an immunosuppressant that has emerged as the most promising longevity compound in preclinical research. At low, intermittent doses (typically weekly), rapamycin upregulates autophagy — your body’s cellular recycling system — clears senescent cells, and has demonstrated lifespan extension in every organism tested. We prescribe it with careful immune and metabolic monitoring, including CBC, metabolic panel, lipids, and fasting glucose at every lab cycle.

Metformin — The most-prescribed diabetes drug in the world, now being studied as a longevity agent in the landmark TAME (Targeting Aging with Metformin) trial. Metformin activates AMPK, reduces hepatic glucose output, improves insulin sensitivity, and has been associated with reduced cancer incidence and cardiovascular events in epidemiological studies. For non-diabetic patients, we prescribe it at lower doses with GI-tolerability monitoring and B12 level tracking.

Senolytics — Compounds that selectively clear senescent cells — the “zombie cells” that accumulate with age and secrete inflammatory signals (the SASP — senescence-associated secretory phenotype) that damage surrounding tissue. Our senolytic protocols use intermittent dosing cycles, typically monthly, with inflammatory marker tracking (hsCRP, IL-6) to verify clearance.

NAD+ Protocols — Nicotinamide adenine dinucleotide is essential for mitochondrial energy production, DNA repair, and sirtuin activation — all of which decline with age. We offer both IV NAD+ infusions for rapid replenishment and oral NMN/NR supplementation for maintenance. NAD+ levels are tracked via intracellular assays to confirm your protocol is actually working.

How We Monitor

Every longevity protocol runs on 90-day cycles. At each reassessment, we check your complete metabolic panel, inflammatory markers, immune function, lipids, and any compound-specific safety markers. We measure your TruAge biological age periodically to track whether your epigenetic clock is actually moving in the right direction. Your protocol evolves with your data — dosing, timing, compound selection, and combination strategies are all adjusted based on what your labs tell us.

This is the SUSTAIN pillar applied to longevity: not a one-time prescription, but an ongoing, data-driven program that evolves as the science advances and your biology responds.

The science of aging has outpaced the medicine most doctors practice. We’ve caught up. → Schedule Your Evaluation