Add Years You'll Actually Want to Live

Over the past two decades, researchers have mapped specific drivers of aging — mTOR overactivation, mitochondrial decline, cellular senescence, NAD+ depletion, epigenetic drift, and chronic low-grade inflammation — and we now have compounds that target each one. Here’s the honest part: most of these are prescribed off-label, the human longevity evidence is promising but still early, and anyone who promises you guaranteed extra years is selling something.

What we offer is the rigor that’s usually missing. Every longevity protocol is built on your DECODE diagnostic foundation, prescribed by your physician, and monitored with quarterly labs — the same discipline we’d apply to any serious therapy. We don’t hand you a bottle and wish you luck; we track biomarkers, measure biological age, and adjust as your data and the science evolve.

The Compounds — and What We Actually Know

Rapamycin (Sirolimus) — An mTOR inhibitor, originally an immunosuppressant, now the most-studied longevity candidate in the lab. At low, intermittent (typically weekly) doses it upregulates autophagy — your body’s cellular recycling — and clears senescent cells. It has extended lifespan across a wide range of model organisms, though the human longevity benefit is still being studied and its use here is off-label. We prescribe it with careful immune and metabolic monitoring (CBC, metabolic panel, lipids, fasting glucose) every lab cycle.

Metformin — The world’s most-prescribed diabetes drug, now under study as a longevity agent in the landmark TAME (Targeting Aging with Metformin) trial. It activates AMPK, lowers hepatic glucose output, and improves insulin sensitivity, with epidemiological associations to reduced cancer and cardiovascular events — associations, not proof. For non-diabetic patients it’s off-label; we prescribe lower doses with GI-tolerability and B12 monitoring.

Senolytics — Compounds that aim to selectively clear senescent “zombie” cells, which accumulate with age and secrete inflammatory signals (the SASP) that damage surrounding tissue. Human evidence is early; our protocols use intermittent (typically monthly) dosing with inflammatory-marker tracking (hsCRP, IL-6).

NAD+ Protocols — NAD+ is essential for mitochondrial energy, DNA repair, and sirtuin activation, all of which decline with age. We offer IV NAD+ for rapid replenishment and oral NMN/NR for maintenance, with levels tracked to confirm the protocol is doing something measurable.

How We Monitor

Every longevity protocol runs on 90-day cycles. At each reassessment we check your complete metabolic panel, inflammatory markers, immune function, lipids, and any compound-specific safety markers, and we periodically measure your TruAge biological age to see whether your epigenetic clock is actually moving the right way. Dosing, timing, and compound selection all adjust based on what your labs show.

This is the SUSTAIN pillar applied to longevity: not a one-time prescription, but an ongoing, data-driven program that evolves as the evidence matures and your biology responds.

The Big 3

• Promising but still early — we’ll be candid about what’s proven and what isn’t.
• Prescribed off-label, by a physician, and monitored on 90-day cycles with real labs.
• We measure your biological age to check whether it’s actually working.

Longevity, Done Like Medicine

If you want these tools, you want them watched closely. Let’s talk about whether they fit your picture.